Plain-English guides to the genes that actually change what you should take and eat. Every claim is cited to a real study. Nothing hyped. Find your gene, then see your own result for free.
The folate–B12 methylation cycle: which forms your genotype can actually use.
The most-Googled gene in consumer genetics, and the most over-sold. Here's the version without the panic.
MTRR · Methylation & B-vitaminsMTHFR gets all the press. Its partner enzyme, MTRR, does the other half of the methylation work, and almost nobody talks about it.
PEMT · Nutrition & liverYour body makes some of its own choline. This gene sets how much, and whether your plate has to make up the difference.
SLC19A1 · Methylation & B-vitaminsThe gatekeeper that pulls folate into your cells
Vitamin D, C and A, plus iron — genes that change how much you make, absorb or need.
Same dose, different blood level. The receptor is part of the reason.
GC · Nutrition & vitaminsYou can get plenty of vitamin D and still test low, if the protein that ferries it around isn't pulling its weight.
CYP2R1 · Nutrition & vitaminsTwo genes can leave you short on vitamin D. This one runs the switch that turns it on.
BCO1 · Nutrition & vitaminsThe gene that decides how much vitamin A you actually get from carrots.
SLC23A1 · Nutrition & vitaminsYour body can't make vitamin C. This gene decides how much of it sticks around.
TMPRSS6 · Nutrition & mineralsTMPRSS6 leans you a little toward lower iron. But iron is one of the few nutrients you can actually take too much of, so the right first step is a blood test, not a supplement.
How your genes shape triglycerides, cholesterol and omega-3 conversion.
Some people eat plenty of fat and carbs and their triglycerides barely move. This variant says you're probably not one of them.
APOE · Nutrition & fatsTwo tiny letters decide how much your LDL moves when you eat butter.
APOA2 · Nutrition & fatsThe CC variant at rs5082 changes how your body processes saturated fat through gene expression, not just calorie counting.
FADS1 · Nutrition & fatsFlax and chia hand you ALA. Your body still has to convert it into the omega-3s that work, and this gene sets how well that goes.
CETP · Fats & lipidsCETP variants are among the strongest genetic signals for HDL cholesterol in the human genome. One of the most replicated findings in lipid genetics.
Caffeine clearance, blood-sugar response and appetite signals.
One liver enzyme clears most of your caffeine, and the version you carry decides how long that afternoon coffee sticks around.
TCF7L2 · MetabolismIf you only ever look up one blood-sugar variant, make it this one. It hits harder than the rest.
FTO · MetabolismA genetic tendency toward higher intake that responds to specific environmental inputs.
The enzymes that handle oxidative stress and detox — and the nutrients that feed them.
The enzyme that mops up the free radicals your own energy production makes.
NQO1 · Nutrition & antioxidantsThe recycler behind your CoQ10's antioxidant punch.
GPX1 · Nutrition & antioxidantsOne small DNA swap sets how briskly your antioxidant enzyme answers when selenium shows up.
GSTM1 · Antioxidant & detoxUnlike a normal SNP, GSTM1 is present or missing — a whole-gene deletion. That makes it interesting, and it makes it hard for a consumer DNA file to read.
Power vs endurance, training response, and the exercise–brain link.
One stop codon decides whether your fast muscle fibers are built for the sprint or the long haul.
ADRB2 · PerformanceOne amino acid, sold as a fat-loss verdict. The real effect is small, and the move is mostly the same either way.
BDNF · CognitiveOne gene, one common typo, and a real difference in how your brain banks the benefits of a workout.
COMT · Cognitive & temperamentOne letter decides whether your prefrontal dopamine gets cleared fast or lingers.
Lactose, the gut microbiome, and how your genes shape what tastes bitter.
Almost every mammal stops digesting milk after weaning. Whether you're an exception comes down mostly to one variant.
FUT2 · Nutrition & gutOne gene decides whether your blood B12 reads high for a reason that has nothing to do with how much you absorb.
TAS2R38 · Taste & dietThe gene that decides whether kale tastes green or like soap.
Variants where the honest call is to avoid — or go easy on — something.
The flush after a drink isn't a quirk. It's your body telling you a toxin is piling up. The research backs that up.
CYP2C19 · SafetyOne liver enzyme, a big say in how some medications work for you.
CYP2C9 · SafetyA drug-handling gene, not a supplement gene. Here's what your result actually tells your doctor.
G6PD · SafetyMegadose vitamin C gets sold as a harmless health habit. Carry a G6PD variant and it isn't.
HFE · SafetyMost supplement advice nudges you toward more iron. Carry certain HFE variants and that's the wrong direction.
SLCO1B1 · SafetyYour liver's statin doorman, and what one letter does to it.
A two-page cited summary of the most actionable nutrition SNPs and safety flags — every line linked to a real study. Print it, share it, bring it to your doctor.
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