Your Report
72 markers read
not retained
Safety flags
5 things your DNA says to be careful with. These protect you; nothing is sold here.
Alcohol hits you harder than most
Your ALDH2 variant slows the breakdown of acetaldehyde, alcohol's toxic intermediate — that's the flush, but it also means regular drinking carries a markedly higher esophageal-cancer risk for you. The reliable lever is to limit or skip alcohol. This is a risk flag, not a diagnosis — discuss it with your doctor.
Go easy on iron supplements
You carry the HFE C282Y variant, the main genotype behind hereditary hemochromatosis (iron overload), and strongest if you're homozygous. Avoid iron-containing supplements, and don't pair high-dose vitamin C with iron-rich meals, unless a doctor has reviewed your iron labs.
Be cautious with iron supplements
You carry the HFE H63D variant, associated with higher iron absorption and serum iron, especially as a homozygote or alongside C282Y. Be cautious with iron supplements unless your iron labs say otherwise.
We held back a suggestion for Gentle Iron (bisglycinate) — only if labs confirm low iron; your safety comes before any recommendation.
Skip high-dose vitamin C
You carry a G6PD-deficiency variant. High-dose vitamin C and other strong oxidants can trigger red-blood-cell breakdown (hemolysis) in G6PD deficiency. Keep vitamin C to normal dietary / RDA amounts. This matters most for males, who carry a single X copy. This is a risk flag, not a diagnosis — a clinician can confirm G6PD status with a simple blood test.
Skip high-dose vitamin C (Mediterranean G6PD)
You carry the G6PD Mediterranean variant, one of the more severe deficiency forms. High-dose vitamin C and other strong oxidants (and fava beans, certain drugs) can trigger red-blood-cell breakdown. Keep vitamin C to normal dietary amounts. This matters most for males, who carry a single X copy. This is a risk flag, not a diagnosis — a clinician can confirm G6PD status with a simple blood test.
Your regimen
12 supplements matched to specific markers in your DNA, each labelled with its evidence tier honestly.
L-Methylfolate (5-MTHF)
Your MTHFR variant slows how efficiently you convert ordinary folic acid into the active folate your cells actually use. L-Methylfolate (5-MTHF) is already in that active form, so it skips the bottleneck. For your genotype, it is simply the more usable folate.
Triglyceride-form Fish Oil (EPA/DHA)
Your FADS1 variant makes you a slower converter of plant-based omega-3 (ALA) into the active EPA and DHA your body runs on. Triglyceride-form fish oil delivers EPA and DHA directly, so you skip the conversion step entirely.
Vitamin D3 + K2
Your GC variant lowers how well your blood transports vitamin D, which raises your risk of running low. Vitamin D3 rebuilds your levels; the K2 alongside it steers calcium into your bones rather than your arteries.
Choline (CDP-Choline / Alpha-GPC)
Your PEMT rs7946 (V175M) variant reduces how much phosphatidylcholine your body makes on its own, so your dietary choline requirement runs higher, and in this genotype choline intake specifically tracks with liver-fat risk. A choline supplement (or choline-rich foods like eggs and liver) helps cover the gap.
L-Methylfolate (5-MTHF)
Your MTHFR A1298C variant modestly lowers folate-activating capacity (it pairs with the more-studied C677T). Methylfolate is the pre-activated form, so it skips the slow conversion step — carriers of these variants show a greater drop in homocysteine when supplemented with methyl-folate.
Lactase Enzyme
Your LCT genotype is the lactase-non-persistent type: as an adult you make little of the enzyme that breaks down lactose. A lactase enzyme taken with dairy does that job for you, so milk and cheese sit easier.
Riboflavin (Vitamin B2)
Because you carry two copies of MTHFR C677T, the enzyme depends more on its riboflavin (B2) cofactor to stay stable. In 677TT individuals specifically, riboflavin supplementation has been shown to lower blood pressure, a cheap, low-risk lever alongside methylfolate.
Triglyceride-form Fish Oil (EPA/DHA)
Your APOA5 -1131C variant raises your triglyceride response to dietary fat. Omega-3s (EPA/DHA) are a well-established way to lower triglycerides, a GENERAL benefit, but one that matters more for you because your genetics push triglycerides up. Pair with limiting refined carbs.
Vitamin D3 + K2
Your CYP2R1 rs10741657 G allele is associated with lower circulating vitamin D and a higher chance of running deficient, so testing your levels and considering D3 is sensible for you. The vitamin-D benefit itself is GENERAL (not unique to your genotype): your genetics raise your baseline risk of being low, not your response to the supplement.
Berberine
Your TCF7L2 result at rs7903146 includes the T variant — the single strongest common genetic signal linked to type 2 diabetes risk. It acts mainly by making the insulin-releasing beta cells in your pancreas less responsive to the meal-time signals (the incretin hormones GLP-1 and GIP) that trigger insulin, with a secondary tendency toward higher glucose output from the liver — so blood sugar can run higher than it otherwise would. This is one of the best-established gene-trait links in nutrigenomics, which makes supporting healthy blood sugar a sensible focus for you (the signal is strongest if you carry two T copies / TT, and more modest with one copy / CT). Berberine is a well-studied plant compound that, across many randomized trials, has been shown to support healthy fasting glucose and insulin sensitivity. Two honesty notes: first, this is a GENERAL glucose-support suggestion — there is no published evidence that berberine works specifically because of your TCF7L2 genotype (the only genotype-stratified studies are unfinished, vendor-sponsored pilots with no posted results). Second, berberine acts mainly on insulin sensitivity and liver glucose output, which is a different mechanism from the insulin-secretion/incretin pathway this variant affects — so think of it as general metabolic support that fits your overall picture, not a targeted match to your DNA. The biggest, best-evidenced levers for T-allele carriers remain diet and physical activity. Please talk with your doctor before starting berberine, especially if you take any blood-sugar or other prescription medications, as it can affect blood sugar and interact with several drugs.
Methylcobalamin (Vitamin B12)
Your MTRR A66G variant alters how efficiently you recycle vitamin B12 in the methylation cycle, nudging homocysteine higher. The B12 benefit here is GENERAL (not unique to your genotype): your variant just makes keeping good B12 status, in the active methylcobalamin form, more worthwhile.
L-Theanine
Your CYP1A2 (rs762551) genotype means you carry at least one C allele, so you tend to clear caffeine more slowly — fully so if you're CC, and to an intermediate degree if you're AC. That's a real, well-studied trait: caffeine can linger longer and its effects feel more prolonged, which is why moderating caffeine and keeping it earlier in the day is the most reliable lever for you. L-theanine is an amino acid found in tea with modest general evidence for supporting a calmer, steadier sense of well-being and helping the body manage everyday stress (typically studied around 200 mg/day). To be straight with you: this is a general benefit, not a genotype-specific one. There's no evidence L-theanine helps slow caffeine metabolizers more than anyone else, controlled trials have not shown it reliably takes the "jitters" off caffeine, and its occasional blood-pressure effect doesn't hold up consistently across studies — so we're not leaning on that either. Think of L-theanine as gentle, low-risk support for calm focus that pairs nicely with your coffee or tea. It supports — it doesn't treat or prevent anything.
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These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
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The full read
Every marker we read, grouped by what it shapes — 72 of 72 interpreted from your file.
Nutrition & Metabolism
24/24How your body handles food, fats, vitamins and minerals — the levers your regimen pulls.
No FTO obesity risk alleles. Standard appetite regulation and satiety signaling.
Homozygous risk. High saturated fat intake (>22g/day) associated with significantly higher BMI and obesity risk for this genotype. Should limit butter, cheese, fatty meat.
Normal PPARG function. Standard adipogenesis (fat cell creation) and insulin sensitivity.
Strongly elevated triglycerides from dietary fat. Omega-3 supplementation and low-fat diet especially important.
Low FADS1 activity. Cannot efficiently convert plant ALA to usable EPA/DHA. Must get omega-3 directly from fatty fish (salmon, sardines, mackerel) or quality fish oil supplement.
Severely reduced beta-carotene conversion. Carrots and sweet potatoes alone won't provide enough vitamin A. Needs retinol from animal sources (liver, eggs, dairy, butter) or preformed supplements.
Non-functional FUT2. ~15-20% lower B12 levels on average. May benefit from B12 supplementation (methylcobalamin form). Also affects gut microbiome composition.
Significantly reduced vitamin D binding protein. High risk of deficiency. D3 supplementation (2000-5000 IU/day) and regular testing recommended.
Two V175M (T) alleles. Markedly reduced internal phosphatidylcholine synthesis; in this genotype dietary choline intake specifically tracks with liver-fat risk. Prioritize choline.
Two G alleles. Associated with the lowest vitamin D levels and highest deficiency risk. Test levels and supplement D3.
Two T alleles — associated with lower hemoglobin (~0.2 g/dL) and iron stores. Check ferritin/iron labs; a gentle iron supplement helps only if they confirm low iron (don't supplement blindly).
Standard MC4R function. Normal hunger and satiety signaling.
Standard leptin receptor function. Normal fullness signaling after meals.
One risk allele. Reduced insulin secretion in response to carbohydrates. Lower-glycemic diet benefits this genotype more than average. Pair carbs with protein/fat.
Reduced mitochondrial antioxidant defense. Higher oxidative stress. Eat antioxidant-rich foods: berries, dark chocolate, leafy greens, green tea. Consider CoQ10 supplement.
One variant allele. Reduced phase II detoxification. Extra cruciferous vegetables are especially beneficial — sulforaphane activates compensatory pathways.
Two copies of the AGT M235T risk allele. Blood pressure is significantly affected by sodium. Actively limit salt and lean on potassium-rich foods (leafy greens, potatoes, beans).
Higher hepatic lipase activity. Tends toward lower HDL (good cholesterol). Exercise and monounsaturated fats (olive oil, avocado, nuts) help raise HDL.
Two copies of HFE C282Y — the main genotype for hereditary hemochromatosis (systemic iron overload). Avoid supplemental iron unless a doctor has reviewed your iron labs.
Two copies of HFE H63D — associated with higher serum iron and transferrin saturation. Use caution with iron supplements; consider checking iron labs.
G6PD-deficiency genotype. Red blood cells are vulnerable to oxidative stress — avoid high-dose vitamin C and known triggers (certain drugs, fava beans) that can cause hemolysis.
Homozygous A1298C. Reduced folate-activating capacity; methylfolate (5-MTHF) is the more usable folate form for you.
Homozygous G — altered B12 utilization linked to higher homocysteine. Ensuring good B12 status (methylcobalamin) is sensible.
Mediterranean-variant G6PD deficiency — one of the more severe forms. Red cells are vulnerable to oxidative stress: avoid high-dose vitamin C, fava beans, and known oxidant drugs.
Uric Acid & Gout
7/7Your genetic load on urate handling.
Optimal SLC2A9/GLUT9 transporter function. Efficiently clears uric acid through the kidneys. SLC2A9 is the single most important gene for serum urate levels, explaining 3-5% of population variance.
Fully functional ABCG2 transporter. Normal uric acid excretion through kidneys and gut. ABCG2 is the second most important gout gene.
Standard GCKR function. Lower metabolic urate production through the purine synthesis pathway.
Optimal SLC2A9 function at this locus. Part of the protective haplotype block.
Protective allele at this SLC2A9 position.
Standard urate excretion at this ABCG2 position.
Heterozygous. PDZK1 is a scaffolding protein that organizes urate transporters at the cell membrane. One variant allele.
Body & Performance
6/6Caffeine, alcohol, lactose, muscle fiber type and more.
Standard pain sensitivity and social bonding response. Normal response to opioid medications.
Caffeine lingers longer in your system. More than 2-3 cups/day associated with increased heart attack risk for this genotype. Afternoon caffeine will disrupt sleep more.
Both copies deficient. Severe alcohol intolerance. Very high esophageal cancer risk if drinking regularly.
Lactase non-persistent. Stops producing lactase enzyme. Dairy causes bloating, gas, discomfort.
Full alpha-actinin-3 expression. Fast-twitch muscle fibers optimized for explosive power, sprinting, and strength.
Normal MC1R function. No increased freckling, red hair, or pain sensitivity from this variant.
Cognitive Performance
15/15Variants studied in relation to memory, learning and mental processing.
Two copies of the G allele at SNAP25, a key synaptic vesicle docking protein. Associated with higher performance IQ in multiple studies. SNAP25 is critical for neurotransmitter release.
Two copies. Associated with the most efficient prefrontal cortex activation during working memory tasks (Zhang et al. 2007). Less neural 'noise' during cognitive work.
Shifts DRD2 long/short isoform balance. Associated with more efficient striatal-prefrontal cortex coupling.
Associated with better sustained attention and working memory performance. The alpha-2A receptor modulates prefrontal norepinephrine signaling.
Affects COMT mRNA processing. Combined with rs4680 (Val/Met), modulates overall dopamine tone in prefrontal cortex. G allele associated with modified executive function.
Two T alleles. Associated with changes in white matter integrity and myelination. NRG1 is critical for neural development and synaptic plasticity.
Common genotype at FOXP2, the 'language gene.' FOXP2 is the first gene directly linked to speech and language ability in humans.
Two copies of the A allele. Associated with higher creative achievement and verbal fluency in large studies. Also linked to bipolar susceptibility — the creativity-mood connection. Voltage-gated calcium channels modulate neural oscillation patterns.
Standard ANK3 expression. Normal axon initial segment formation and neural excitability.
Standard DCDC2 function. This gene is involved in neuronal migration in the cerebral cortex during development, critical for reading circuits.
Ataxin-1 variant associated with higher educational attainment in GWAS (Lee et al. 2018, n=1.1M). Effect is tiny per-SNP but well-replicated.
C allele associated with higher cognitive ability in Savage et al. 2018 (n=269K). MicroRNA region affecting gene regulation in brain tissue.
Typical NRXN1 synaptic adhesion function. Neurexins are critical for synapse formation and neurotransmitter release.
Normal cathepsin D function. This lysosomal protease clears amyloid precursors. GG genotype is protective against accelerated cognitive aging.
Two C677T copies. Significant folate metabolism reduction. Methylfolate supplementation strongly recommended. Low folate directly impacts neurotransmitter synthesis and DNA repair.
Memory & Neuroplasticity
5/5How your brain forms and keeps memories.
Standard activity-dependent BDNF release. Exercise provides a strong cognitive boost — your brain responds well to physical activity for memory and learning.
Standard hippocampal size. Normal baseline for memory structure.
Best memory performance. Vivid recall of events and experiences.
Normal DBH activity. Efficiently converts dopamine to norepinephrine. Exercise produces a clean norepinephrine boost that significantly improves sustained attention. This genotype responds especially well to physical activity before cognitive tasks.
Homozygous for the allele associated with better sustained attention via the cholinergic system. Stronger nicotinic receptor function supports vigilance and focus during monotonous tasks.
Temperament & Reward
10/10Dopamine, stress resilience, empathy and bonding.
Fast dopamine clearance. Performs better under stress, calmer in crisis. Lower baseline dopamine — needs more stimulation to stay engaged. More likely to take risks, less likely to ruminate.
Standard dopamine receptor availability. Normal reward sensitivity.
Normal tryptophan hydroxylase-2 activity. Standard emotional reactivity.
Optimal oxytocin receptor expression. More empathetic, handles stress better, more optimistic. Better at reading social cues.
Arg/Arg genotype. Stronger beta-adrenergic activation during stress. More intense fight-or-flight surges. May respond differently to beta-agonist medications (albuterol).
Typical 5-HT2A receptor density. Standard SSRI response expected.
Normal FAAH enzyme activity. Lower baseline anandamide (the 'bliss molecule'). Reduced placebo response, less susceptible to vague feel-good marketing. More skeptical by default — needs concrete evidence to feel reward.
Normal GABRA2 expression. Typical GABAergic inhibitory signaling. Standard impulse control baseline.
Normal FKBP5 function. Typical HPA axis feedback. Standard cortisol response to stress — neither amplified nor dampened.
Normal cannabinoid receptor 1 expression. Typical endocannabinoid reward signaling and stress-relief response.
Sleep & Chronotype
2/2Your circadian wiring — lark or owl.
Delayed circadian preference. Naturally inclined toward later bedtimes and later waking.
Standard DEC2 function. Requires typical 7-9 hours of sleep.
Taste & Smell
2/2The quirks of how you perceive flavor.
Cannot taste PROP/PTC bitter compounds. Vegetables like broccoli and kale taste milder.
Standard olfactory receptor. Cilantro tastes normal/herbal.
Longevity
1/1Aging-associated variants.
No longevity-associated G allele. Average baseline — lifestyle factors still dominate.